Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pacinian corpuscle development involves multiple Trk signaling pathways.

J Sedý1, V Szeder, J M Walro

  • 1Institute of Anatomy, Charles University, First Faculty of Medicine, U nemocnice 3, 128-00 Prague, Czech Republic.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|September 18, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deuterated water impact on the luminescence of quantum dots.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy·2026
Same author

Development of an integrative cross-omics approach for conceptual adverse outcome pathway network construction.

Environment international·2026
Same author

East-to-west human dispersal into Europe 1.4 million years ago.

Nature·2024
Same author

Metabolic cardio- and reno-protective effects of empagliflozin in a prediabetic rat model.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2021
Same author

Determination of deuterium oxide content in water based on luminescence quenching.

Talanta·2018
Same author

"Daisy-like" crystals: A rare and unknown type of urinary crystal.

Clinica chimica acta; international journal of clinical chemistry·2017
Same journal

Multi-stage transcriptome analysis reveals genetic orchestration of rat testis development.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Three-dimensional observation of the muscle-tendon integration process in mouse embryos.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH-1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode-derived cells in the brain.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Prenatal sexual dimorphism in human pelvic tilt at the onset of fetal ossification.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Meet the editorial team. An interview with Ralph Marcucio, Assistant Editor, University of California San Francisco, United States.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Editorial highlights.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
See all related articles

Neurotrophin-3 (NT3) is crucial for developing Pacinian corpuscles in mice, regulating their density and sensory neuron survival. Other neurotrophins like BDNF and NT4 also play roles, but NT3

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Sensory Biology

Background:

  • Pacinian corpuscles are mechanoreceptors essential for touch sensation.
  • Neurotrophins and their receptors (Trk) are vital for neuronal development and survival.

Purpose of the Study:

  • To investigate the role of neurotrophins (NGF, BDNF, NT3, NT4) and their Trk receptors in the development of crural Pacinian corpuscles.
  • To determine the specific contributions of each neurotrophin and receptor to corpuscle formation and afferent survival.

Main Methods:

  • Utilized knockout mouse models lacking specific neurotrophins or Trk receptors.
  • Examined the density and morphology of crural Pacinian corpuscles and their afferent nerve fibers.
  • Analyzed the coexpression patterns of Trk receptors on afferent neurons.

Related Experiment Videos

Main Results:

  • NT3 deficiency caused the most severe deficits in Pacinian corpuscle development and afferent survival.
  • BDNF and NT4 also contributed, while NGF had minimal impact.
  • Absence of NT3 resulted in no Pacinian corpuscles, even in combined deficiencies with other neurotrophins.
  • NT3 signaling, particularly via TrkA and TrkB, was more critical than NT3/TrkC signaling.

Conclusions:

  • Multiple neurotrophins, with NT3 being paramount, regulate the density of crural Pacinian corpuscles.
  • Neurotrophins likely influence corpuscle development by promoting sensory neuron survival.
  • NT3 signaling through TrkA and TrkB receptors is essential for the development of Pacinian corpuscle afferents.