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Thalamic deep brain stimulation for essential tremor: recommendations for long-term outcome analysis
J D Putzke1, R E Wharen, A A Obwegeser
1Department of Neurology, Mayo Clinic, Jacksonville, FL 32224 , USA.
Summary
Thalamic deep brain stimulation (DBS) effectively controls essential tremor (ET), improving daily activities and reducing tremor severity. Long-term results show sustained efficacy and good tolerability for most patients.
Area of Science:
- Neurology
- Neurosurgery
Background:
- Essential tremor (ET) is a common neurological disorder characterized by involuntary shaking.
- Current treatments for ET have limitations, necessitating exploration of advanced therapies.
Purpose of the Study:
- To evaluate the long-term efficacy of thalamic deep brain stimulation (DBS) in managing essential tremor.
- To assess the impact of DBS on tremor severity and activities of daily living.
Main Methods:
- A cohort of 52 ET patients received thalamic DBS.
- Patients underwent comprehensive assessments of tremor and daily function at multiple postoperative intervals up to three years.
Main Results:
- Thalamic DBS demonstrated significant improvements in both subjective and objective measures of tremor and activities of daily living.
- Sustained tremor control was observed, with stimulation settings remaining stable post-initiation.
- Dysarthria was a noted side effect, particularly with bilateral stimulation.
Conclusions:
- Thalamic DBS is a well-tolerated and effective therapeutic option for essential tremor.
- The study provides recommendations for evaluating long-term outcomes of DBS for ET.