Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model for cardiopulmonary bypass redesign.

R C Groom1, D S Likosky, R J Forest

  • 1Maine Medical Center, Cardiac Surgery Division, Portland, ME 04102, USA. groomr@mmc.org

Perfusion
|September 21, 2004
PubMed
Summary

This study monitored brain injury precursors during cardiac surgery. Findings reveal specific bypass procedures increase embolic activity and hypoperfusion, informing safer surgical techniques.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Properties of Heavy Cosmic Nuclei Phosphorus, Chlorine, Argon, Potassium, and Calcium: Results from the Alpha Magnetic Spectrometer.

Physical review letters·2026
Same author

Benign functional anorectal conditions: a multi-centre analysis of rectal stump symptomatology in patients undergoing stoma formation.

Techniques in coloproctology·2026
Same author

Chronic activation of the small-conductance, calcium-activated potassium channel precipitates age-dependent depressive-like behavior and cognitive deficits and reduces klotho concentration.

Neuroscience applied·2025
Same author

Antiprotons and Elementary Particles over a Solar Cycle: Results from the Alpha Magnetic Spectrometer.

Physical review letters·2025
Same author

Solar Modulation of Cosmic Nuclei over a Solar Cycle: Results from the Alpha Magnetic Spectrometer.

Physical review letters·2025
Same author

Mechanical circulatory support as a bridge to delivery in a pregnant patient with dilated cardiomyopathy and acute heart failure: a case report.

International journal of obstetric anesthesia·2024

Area of Science:

  • Neurology
  • Cardiovascular Surgery
  • Biomedical Engineering

Background:

  • Cardiac surgery can cause brain injuries via embolism and hypoperfusion.
  • Cardiopulmonary bypass (CPB) is implicated in these neurological deficits.
  • Understanding CPB's role is crucial for preventing brain injury.

Purpose of the Study:

  • To understand processes causing embolic activity during CPB.
  • To investigate cerebral hypoperfusion and hemodynamic changes during CPB.
  • To link specific surgical events to neurological injury precursors.

Main Methods:

  • Developed a system for simultaneous recording of physiological data, embolic activity, and cerebral oxygenation (NIRS).
  • Synchronized all data with surgical video for detailed analysis.

Related Experiment Videos

  • Related embolic events and NIRS changes to surgical and CPB care processes via video review.

    • Main Results:

    • Observed significant patient variation in embolic counts and NIRS.
    • Identified specific CPB events (e.g., venous drainage, air entrainment, drug injection) linked to increased embolism.
    • Correlated NIRS changes with hypotension and heart positioning during grafting.

    Conclusions:

    • The developed monitoring system provides insights into CPB's contribution to neurological injury precursors.
    • Data can guide surgical teams in refining CPB systems and techniques to minimize brain injury risk.