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Isolation, Identification, and Purification of Murine Thymic Epithelial Cells
Published on: August 8, 2014
Isolation and identification of a new thymic peptide from calf thymus
Xi-Ming Qin1, Ming-Xing Duan, Bin Deng
1State Key Laboratory of Biomembranes and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, 100084, China.
Abstract:
Various thymic peptides (including thymulin, thymic humoral factor, thymopoietin, etc.) play important roles in the process of T cell maturation and development. We isolated a new peptide from calf thymus and named it thymus activity factor II (TAF-II). A yield of 0.92 mg of TAF-II was purified from 500 g calf thymus. Analysis by LC/MSD-Trap showed the amino acid sequence of this hexapeptide to be Glu-Ala-Lys-Ser-Gln-Gly-OH with molecular weight 618.5 daltons. We have also begun to investigate the influence of TAF-II.
