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CARD15/NOD2 single nucleotide polymorphisms do not confer susceptibility to type I psoriasis
1Centre for Integrated Genetic Medical Research, University of Manchester, Manchester, UK. darren72@fs1.ser.man.ac.uk
The British Journal of Dermatology
|September 21, 2004
Summary
Genetic analysis of the CARD15 gene in psoriasis patients revealed no association between caspase recruitment domain family, member 15 (CARD15) single nucleotide polymorphisms (SNPs) and type I psoriasis development. This study found no evidence linking CARD15 SNPs to the disease.
Area of Science:
- Genetics
- Dermatology
- Immunology
Background:
- Psoriasis and Crohn's disease share a susceptibility locus on chromosome 16q.
- Mutations in the CARD15 gene are linked to Crohn's disease susceptibility.
- Comorbidity suggests a potential shared genetic factor between these conditions.
Purpose of the Study:
- To investigate the role of CARD15 gene single nucleotide polymorphisms (SNPs) in the development of type I psoriasis.
- To determine if genetic variations in CARD15 contribute to the pathogenesis of psoriasis.
Main Methods:
- Genotyping of eight CARD15 SNPs in 148 type I psoriasis patients and 192 controls.
- Comparison of genotype, allele, and SNP haplotype frequencies between cases and controls.
- Population stratification testing was performed.
Main Results:
- No significant differences in genotype, allele, or haplotype frequencies were found between psoriasis patients and controls.
- The study did not identify any association between CARD15 SNPs and type I psoriasis.
Conclusions:
- This comprehensive assessment of CARD15 SNPs in type I psoriasis provides no evidence for their involvement in the disease's pathogenesis.
- The CARD15 gene is unlikely to be a significant genetic factor in type I psoriasis.