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DC-SIGN: binding receptors for hepatitis C virus
Quan-Chu Wang1, Zhi-Hua Feng, Qing-He Nie
1PLA Center for Diagnosis and Treatment for Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China. Quanchuwang998@hotmail.com
Chinese Medical Journal
|September 21, 2004
Summary
Dendritic cell-specific adhesion receptor (DC-SIGN) is a key binding receptor for hepatitis C virus (HCV). Targeting DC-SIGN offers potential strategies to limit HCV spread and influence immune responses.
Area of Science:
- Immunology
- Virology
- Cell Biology
Background:
- Hepatitis C virus (HCV) utilizes specific receptors for cellular entry and infection.
- Dendritic cells (DCs) play a crucial role in immune responses and pathogen recognition.
- Dendritic cell-specific adhesion receptor (DC-SIGN) is a mannose-binding C-type lectin involved in DC function.
Purpose of the Study:
- To review recent developments in hepatitis C virus (HCV) binding receptors.
- To specifically examine the role of dendritic cell-specific adhesion receptor (DC-SIGN) in HCV infection.
Main Methods:
- Literature search of Chinese and English articles from 2000-2003 using MEDLINE and Chinese language databases.
- Selection of relevant articles focusing on DC-SIGN and HCV binding receptors.
- Data extraction from 40 selected articles.
Main Results:
- DC-SIGN facilitates infection by HCV and other pathogens (HIV, Ebola, CMV, Mycobacterium tuberculosis).
- DC-SIGN mediates viral entry into DCs and can concentrate virus on target cells.
- HCV E2 interaction with DC-SIGN may impair DC-T cell interactions during antigen presentation.
Conclusions:
- DC-SIGN acts as a high-affinity binding receptor for HCV.
- Targeting DC-SIGN presents a potential clinical strategy to restrict HCV dissemination and pathogenesis.
- Modulating DC-SIGN could be used to manipulate immune responses in autoimmunity and cancer.