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Detection of c-sis proto-oncogene transcripts by direct enzyme-labeled cDNA probes and in situ hybridization

J T McClintock1, I J Chan, S R Thaker

  • 1Digene Diagnostics, Inc., Silver Spring, Maryland 20904.

In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association
|February 1, 1992
PubMed

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Labeling DNA Probes

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Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
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In-situ Hybridization

In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
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