Related Experiment Video
Updated: Aug 22, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Racial differences in lipid-lowering agent use in medicaid patients with cardiovascular disease
David Litaker1, Siran M Koroukian
1Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA. dxl25@po.cwru.edu
Insights
Minorities with cardiovascular disease (CVD) are less likely to use lipid-lowering agents (LLAs) due to underuse before and after diagnosis. Targeted strategies are needed to reduce disparities in CVD preventive care.
Area of Science:
- Cardiovascular Medicine
- Health Disparities Research
- Pharmacotherapy Outcomes
Background:
- Racial disparities in cardiovascular disease (CVD) outcomes are established, but the role of preventive care processes remains unclear.
- Understanding preventive care utilization is crucial for addressing unequal CVD outcomes.
Purpose of the Study:
- To investigate the association between race and the use of lipid-lowering agents (LLAs) among individuals with incident CVD.
- To examine prior LLA use, initiation of LLAs, and discontinuation of LLAs in relation to race.
Main Methods:
- Retrospective analysis of fee-for-service Medicaid claims data from 1993-1998.
- Included continuously enrolled individuals under 65 with a new CVD diagnosis (n=14,833).
- Assessed LLA pharmacy claims for 24 months around the CVD event; multivariable logistic regression controlled for covariates.
Main Results:
- Minority individuals were less likely to have prior LLA use (aOR=0.64), initiate new prescriptions (aOR=0.62), or continue LLA therapy (aOR=0.74).
- Overall, 26.4% of individuals used LLAs, with 78.6% of users obtaining refills.
Conclusions:
- Publicly insured minorities with prescription coverage experience less benefit from CVD preventive care, including LLAs.
- Provider-initiated underprescription and patient-initiated discontinuation contribute to LLA underuse among minorities.
- Strategies targeting LLA underuse across the care continuum are essential to mitigate CVD outcome disparities.
Background:
Racial differences in chronic cardiovascular disease (CVD) outcomes are well described, whereas less is known about the process of CVD preventive care and its potential contribution to disparate outcomes.
Objective:
The objective of this study was to examine the association between race and 1) prior use of a lipid-lowering agent (LLA), 2) LLA initiation, and 3) LLA discontinuation among individuals with an incident medical claim for CVD.
Research Design:
Retrospective claims analysis.
Subjects:
We studied continuously enrolled, fee-for-service Medicaid recipients <65 with a new medical claim for 1 of 15 CVD-related diagnoses or procedures from 1993 to 1998 (n = 14,833).
Measures:
Pharmacy claims history reflecting previous, new, and ongoing LLA use were reviewed for the 24-month period around a new CVD claim. Multivariable logistic regression assessed the independent effect of minority status on new and ongoing LLA use controlling for clinical and demographic characteristics.
Results:
A total of 3924 (26.4%) individuals submitted LLA pharmacy claims. A total of 3668 of 4668 (78.6%) previous or new users obtained > or =1 refill. Minorities were less likely to have previously used LLA (adjusted odds ratio [AOR], 0.64; 95% confidence interval [CI], 0.58-0.70), to receive a new prescription (AOR, 0.62; 95% CI, 0.54-0.71), or to continue use, as evidenced by subsequent refill claims (AOR, 0.74; 95% CI, 0.62-0.87).
Conclusions:
Publicly insured minorities with prescription coverage benefit less often from preventive care before or after a CVD diagnosis, resulting, in part, from providers' failure to initiate therapy and patients' failure to continue it. To reduce widening disparities in cardiovascular outcomes, strategies that target LLA underuse by minorities throughout the process of care are needed.
Related Concept Videos
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
Atherosclerosis III: Management
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Drug Dosing: Obese Patients
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacogenomics: Identification of New Drug Targets