Mechanisms of roof plate formation in the vertebrate CNS
Victor V Chizhikov1, Kathleen J Millen
1Department of Human Genetics, University of Chicago, 920 East 58th Street, CLSC 319, Chicago, Illinois 60637, USA.
Abstract:
The roof plate is an embryonic organizing centre that occupies the dorsal midline of the vertebrate neural tube. During early CNS development, the roof plate produces secreted factors, which control the specification and differentiation of dorsal neuronal cell types. An appreciation of the signalling properties of the roof plate has prompted an enhanced interest in this important organizing centre, and several recent studies have begun to illuminate the molecular mechanisms of roof plate development.
More Related Videos
09:53Culture of Isolated Floor Plate Tissue and Production of Conditioned Medium to Assess Functional Properties of Floor Plate-released Signals
Published on: February 11, 2014
04:17Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices
Published on: March 8, 2024
Related Concept Videos
Neurulation
Neurogenesis and Regeneration of Nervous Tissue
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Determination
