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Renal function in relation to three candidate genes in a Chinese population
Ji-Guang Wang1, Lifang Liu, Laura Zagato
1Ruijin Hospital, Shanghai Institute of Hypertension, Shanghai Second Medical University, Ruijin 2nd Road 197, 200025 Shanghai, China. jiguangwang@netscape.net
Journal of Molecular Medicine (Berlin, Germany)
|September 21, 2004
Summary
Genetic polymorphisms in ACE, alpha-adducin, and aldosterone synthase influence renal function. This study in Chinese Han subjects found serum uric acid levels are associated with the ACE D allele, particularly in carriers of alpha-adducin Gly and aldosterone synthase C alleles.
Area of Science:
- Genetics
- Nephrology
- Cardiovascular Disease
Background:
- Previous research identified joint influence of ACE (I/D polymorphism), alpha-adducin (Gly460Trp), and aldosterone synthase (-344C/T) genes on renal function in a white population.
- Understanding the genetic basis of renal function is crucial for managing hypertension and related conditions.
Purpose of the Study:
- To investigate associations between serum creatinine and uric acid concentrations and the ACE, alpha-adducin, and aldosterone synthase polymorphisms in a Chinese population.
- To confirm and extend previous findings on the combined genetic influence on renal function.
Main Methods:
- Genotyping of 471 ethnic Han Chinese subjects from 125 nuclear families.
- Population-based association analyses using generalized estimating equations (GEE).
- Family-based association analyses using quantitative transmission disequilibrium test (QTDT).
Main Results:
- Serum uric acid, but not serum creatinine, was positively associated with the ACE D allele (DD homozygotes had higher concentrations).
- This association was significant in carriers of alpha-adducin Gly and/or aldosterone synthase C alleles.
- Family-based analyses confirmed the association between serum uric acid and ACE D allele transmission in carriers of the alpha-adducin Gly allele.
Conclusions:
- The study supports the concept that ACE, alpha-adducin, and aldosterone synthase genetic polymorphisms jointly influence renal function in the Chinese population.
- Findings extend previous observations and highlight the role of these gene variants in modulating serum uric acid levels and renal function.