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Updated: Jul 31, 2026

Functional Characterization of Na+/H+ Exchangers of Intracellular Compartments Using Proton-killing Selection to Express Them at the Plasma Membrane
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The sodium-iodide symporter

C H Baker1, J C Morris

  • 1Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.

Current Drug Targets. Immune, Endocrine and Metabolic Disorders
|September 24, 2004
PubMed

The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant. Cloning and characterization of NIS has more recently allowed research into its use in non-thyroidal cancers through gene transfer for both diagnosis and treatment.

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