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Related Experiment Videos

The non-existent aging program: how does it work?

Dale E Bredesen1

  • 1Buck Institute for Age Research, University of California, San Francisco, 8001 Redwood Blvd, Novato, CA 94949, USA. dbredesen@buckinstitute.org

Aging Cell
|September 24, 2004
PubMed
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Aging may be programmed, not just a result of wear and tear. Understanding this programmed aging could reveal new targets for longevity and disease prevention.

Area of Science:

  • Gerontology and molecular biology.
  • Evolutionary biology and genetics.

Background:

  • Aging and lifespan are traditionally viewed as non-programmatic.
  • Existing theories suggest aging results from evolutionary trade-offs favoring early fitness over late survival.

Purpose of the Study:

  • To discuss recent data suggesting programmatic aspects of aging and lifespan determination.
  • To draw analogies between programmed cell death and programmed organismal death.
  • To explore potential therapeutic targets for longevity and disease prevention.

Main Methods:

  • Review of recent scientific data.
  • Comparative analysis of aging processes.
  • Conceptual framework development.

Main Results:

Related Experiment Videos

  • Emerging data implicates potentially programmatic elements in aging.
  • Analogies drawn between programmed cell death and organismal aging processes.

Conclusions:

  • The possibility of a programmatic aspect to aging warrants further investigation.
  • Recognizing programmed aging may enhance identification of therapeutic targets for longevity and disease prevention.