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Updated: Aug 10, 2026
A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
Published on: April 11, 2014
Serum ascorbic acid concentrations in previously unsupplemented greyhounds after administration of a single dose of
K C Scott1, R C Hill, D D Lewis
1Department of Small Animal Clinical Sciences and the Center for Veterinary Sports Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
Abstract:
Plasma vitamin C concentrations (mean + SD) were measured after a large (1 g) dose of vitamin C was administered orally or intravenously to each of four trained greyhounds in a randomized cross-over design. Concentrations increased (p<0.05) for 2 h but returned to baseline by 6 h after supplementation. Peak concentrations were greater (p<0.01) after intravenous than oral administration (6.1+/-1.2 vs. 0.54+/-0.23 mg/dl). This suggests that vitamin C must be administered many times daily to maintain plasma concentrations above normal.
