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Abnormal behavior in children with temporal lobe epilepsy and ganglioglioma

Catarina A Guimarães1, Renata C Franzon, Elisabete A P Souza

  • 1Department of Neurology, FCM, UNICAMP Campinas, SP, Brazil.

Epilepsy & Behavior : E&B
|September 24, 2004
PubMed

Insights

Pediatric temporal lobe epilepsy surgery usually controls seizures but can worsen behavior in some children. This is especially true for those with temporal lobe ganglioglioma, even after successful seizure control.

Area of Science:

  • Pediatric Neurology
  • Neurosurgery
  • Developmental Neuroscience

Background:

  • Temporal lobe epilepsy (TLE) in children presents diverse clinical, EEG, and etiological features.
  • Epilepsy surgery for TLE in childhood often yields good seizure control.
  • Postoperative behavioral deterioration can occur in a subset of pediatric patients.

Observation:

  • Two young girls (2 and 6 years) with refractory TLE caused by temporal lobe ganglioglioma were studied.
  • Both patients displayed pre-existing aggression and hyperactivity linked to their epilepsy.
  • Behavioral issues intensified post-surgery despite achieving complete seizure remission.

Findings:

  • Temporal lobe ganglioglioma-associated epilepsy in children can present with significant behavioral comorbidities.
  • Surgical intervention for TLE in this cohort may exacerbate behavioral disturbances, including aggression and hyperactivity.
  • Complete seizure control post-surgery does not preclude worsening of behavioral symptoms.

Implications:

  • Clinicians should counsel families about the potential for postoperative behavioral decline in pediatric TLE, particularly with developmental tumors.
  • Neurosurgeons and neurologists must consider behavioral monitoring alongside seizure outcomes in pediatric epilepsy surgery.
  • Further research is needed to understand the mechanisms underlying behavioral changes after TLE surgery in children with specific tumor types.

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