Hierarchy of regulatory events in sensory placode development

Cranial placodes are a uniquely vertebrate characteristic; they form the paired sense organs of the eyes, ears and nose, in addition to the distal parts of some of the cranial sensory ganglia. These focal ectodermal thickenings have been studied from an embryological perspective in a diversity of organisms, revealing tissue interactions that are crucial for the morphological formation of the different placodes. In recent times, there has been a renewed interest in understanding the induction and differentiation of these deceptively simple ectodermal regions. This has led to a wealth of information on the molecular cues governing these processes. In particular, the integration of signals at the level of 'placode-specific' enhancers is beginning to provide a glimpse into the complexity of genetic networks that function within this embryonic cell population to generate key components of the peripheral nervous system.