Related Experiment Video
Updated: Aug 22, 2026

Expanding the Toolkit for In Vivo Imaging of Axonal Transport
Published on: December 23, 2021
cAMP, tubulin, axonal transport, and regeneration
1Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Abstract:
Mounting a regenerative response after injury is a multistep process for PNS neurons. The reason for failure of mammalian CNS neurons to regenerate successfully may involve more than one of those steps. Han et al. [Exp. Neurol. 189 (2004) 293] and others show that increasing cAMP levels in neuronal cell bodies elicits a partial regenerative response, altering expression of tubulin isotypes but not expression of other growth-associated genes or rate of axonal transport. This approach allows identification of specific steps in the regenerative response and the roles played by these steps.
Related Concept Videos
Assembly of Complex Microtubule Structures
Microtubule Associated Motor Proteins
Neurogenesis and Regeneration of Nervous Tissue
Neurons: The Axon
The axon attaches to the cell body at a cone-shaped elevation called the axon hillock. The initial part of the axon, closest to the hillock, is known as the initial segment.
Microtubule Instability
Microtubule Associated Proteins (MAPs)
