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Published on: September 27, 2013
T cells in the pathogenesis of systemic lupus erythematosus
1Division of Rheumatology and Immunology, Department of Medicine, University of Miami and the Miami Veterans Affairs Medical Center, Miami, FL 33136, USA. rhoffman@med.miami.edu
Abstract:
Recent studies in patients with systemic lupus erythematosus (SLE) have demonstrated that autoantigen-reactive T cells can be isolated from peripheral blood and that such cells can support autoantibody production ex vivo, suggesting that they may have a central role in the pathogenesis of disease. In addition, recent work has identified and characterized signaling abnormalities in T cells from SLE that may be fundamental to the disease. This review will examine the role of T cells in the pathogenesis of SLE and it will consider pathogenic mechanisms by which T cells escape normal of immunological tolerance. The focus will be on recent studies characterizing autoantigen-reactive human T cells and signaling abnormalities identified in T cells from patients with SLE.
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