Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prostate movement during simulation resulting from retrograde urethrogram compared with "natural" prostate movement.

Yu-Ming Liu1, Stella Ling, K M Langen

  • 1Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.

International Journal of Radiation Oncology, Biology, Physics
|September 24, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A High Decipher Genomic Risk Score Is Associated with Major Pathological Progression in Patients Undergoing Active Surveillance for Prostate Cancer.

European urology oncology·2026
Same author

Determining Optimal Patient Selection for High-intensity Focused Ultrasound for Prostate Cancer.

European urology focus·2025
Same author

The Natural History of Confirmed Grade Group 1 Prostate Cancer Managed with Active Surveillance in the Modern Era.

European urology oncology·2025
Same author

Gleason Grade Group 3 Represents a Spectrum of Disease: Results from a Large Institutional Cohort.

European urology focus·2025
Same author

Targeted Biopsy Is Sufficient for Men on Active Surveillance for Early-Stage Prostate Cancer.

The Journal of urology·2024
Same author

Determining Long-term Prostate Cancer Outcomes for Active Surveillance Patients Without Early Disease Progression: Implications for Slowing or Stopping Surveillance.

European urology oncology·2024
Same journal

Single Percussive Ventilation Breath-hold Imaging and Delivery in Lung Tumor Stereotactic Ablative Radiation Therapy: Initial Observations From a Prospective Clinical Trial.

International journal of radiation oncology, biology, physics·2026
Same journal

Proton beam therapy in nonmetastatic rhabdomyosarcoma: Outcome, prognostic factors and the effect of timing of radiation therapy.

International journal of radiation oncology, biology, physics·2026
Same journal

Hypofractionated Proton Reirradiation for Recurrent Glioblastoma: Clinical and Dosimetric Outcomes from a Large Single Institution Series.

International journal of radiation oncology, biology, physics·2026
Same journal

Gastrointestinal Motility-Induced Interplay in Pancreas Proton Therapy: Motion Simulation and Dosimetric Impact.

International journal of radiation oncology, biology, physics·2026
Same journal

Intra-fractional Voxel-wise Anatomical Motion Tracking Guided by Multimodal Respiratory Surrogates in Radiotherapy: Framework Development and Multi-Center Validation.

International journal of radiation oncology, biology, physics·2026
Same journal

A Gaussian-based planning approach for robust dose-escalated stereotactic body proton therapy.

International journal of radiation oncology, biology, physics·2026
See all related articles

Retrograde urethrography (UG) causes minimal prostate displacement during radiotherapy simulation. This prostate movement is clinically insignificant when accounting for natural prostate motion, ensuring accurate treatment targeting.

Area of Science:

  • Radiation oncology
  • Medical imaging
  • Prostate cancer treatment

Background:

  • Retrograde urethrography (UG) is a common simulation tool for defining the prostate apex in radiotherapy.
  • Concerns exist regarding potential prostate displacement caused by the UG procedure.

Purpose of the Study:

  • To investigate and quantify prostate movement induced by retrograde urethrography (UG).
  • To assess the clinical significance of UG-induced prostate displacement in radiation therapy planning.

Main Methods:

  • 24 prostate cancer patients undergoing 3D conformal radiotherapy with implanted gold markers were studied.
  • Marker seed positions were compared between simulation and pre-treatment portal images using DRR.
  • Prostate movement (superior-inferior, anteroposterior) was measured from 402 portal images using specialized software and statistical analysis.

Related Experiment Videos

Main Results:

  • Observed natural, nonrandom prostate movement averaging 1 mm superiorly and 0.82 mm anteriorly.
  • Prostate movement after UG was slightly greater than natural movement, with average differences of 2.64 mm (superior-inferior) and 2.24 mm (anteroposterior).
  • Differences in movement after UG were statistically significant (p=0.004 and p=0.035, respectively).

Conclusions:

  • Retrograde urethrography induces a small prostate displacement.
  • This displacement is clinically insignificant when natural prostate motion is considered.
  • UG can be safely used in radiotherapy simulation without compromising treatment accuracy.