Vertebrate thymus and the neurotrophin system

An immunomodulary role has been proposed for growth factors included in the family of neurotrophins. This is supported by the presence of both neurotrophins and neurotrophin receptors in the immune organs and some immunocompetent cells, the in vitro and in vivo effects of the neurotrophins on the immune cells, and the structural changes of lymphoid organs in mice deficient in neurotrophins and their receptors. The current data strongly indicate that neurotrophins regulate the biology of thymic stromal cells and T cells, including survival, and are involved in the thymic organogenesis. This review compiles the available data about the occurrence and distribution of neurotrophins and their signaling receptors (Trk proteins and p75(NTR)) in the vertebrate thymus and the possible contribution of these molecules to the thymic microenvironment and, therefore, to the T cells differentiation.