Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional imaging in Lhermitte-Duclose disease.

Madakasira V Padma1, Martin Jacobs, Pam Sequeira

  • 1Wallace-Kettering Neurosciences Institute, Kettering Medical Center, OH 45429, USA.

Molecular Imaging and Biology
|September 24, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trait-mediated responses of caterpillar communities to spongy moth outbreaks and subsequent tebufenozide treatments.

Ecological applications : a publication of the Ecological Society of America·2023
Same author

Salinity reduces site quality and mangrove forest functions. From monitoring to understanding.

The Science of the total environment·2022
Same author

Diagonistic Dyspraxia and Apraxia in NMDA Encephalitis: A Rare Etiology.

Movement disorders clinical practice·2021
Same author

Relationship between white matter glucose metabolism and fractional anisotropy in healthy and schizophrenia subjects.

Psychiatry research. Neuroimaging·2020
Same author

A novel, integrated PET-guided MRS technique resulting in more accurate initial diagnosis of high-grade glioma.

The neuroradiology journal·2016
Same author

Primary angiitis of the central nervous system: a study of histopathological patterns and review of the literature.

Folia neuropathologica·2014

Metabolic imaging of Lhermitte-Duclos Disease (LDD) shows tumor hypermetabolism with FDG-PET, moderate methionine uptake, and no choline uptake. This functional imaging reflects LDD

Area of Science:

  • Neuro-oncology
  • Medical imaging
  • Biochemistry

Background:

  • Lhermitte-Duclos Disease (LDD) is a rare cerebellar tumor.
  • Metabolic characterization is crucial for understanding LDD pathology.

Observation:

  • A 30-year-old woman with LDD underwent comprehensive metabolic assessment.
  • Positron emission tomography (PET) and magnetic resonance spectroscopy (MRS) were utilized.

Findings:

  • FDG-PET demonstrated significant tumor hypermetabolism.
  • 11C-methionine PET showed moderate uptake, while 11C-choline PET revealed no uptake.
  • 1H-MRS indicated elevated lactate and reduced choline and myoinositol levels.

Implications:

  • Functional imaging findings correlate with LDD's dual neoplastic and hamartomatous nature.

Related Experiment Videos

  • Metabolic profiles can aid in diagnosing and characterizing LDD.
  • This study highlights the utility of multimodal functional imaging in LDD.