Functional imaging in Lhermitte-Duclose disease
Related Experiment Video
Updated: Aug 22, 2026
Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
Published on: February 28, 2021
Madakasira V Padma1, Martin Jacobs, Pam Sequeira
1Wallace-Kettering Neurosciences Institute, Kettering Medical Center, OH 45429, USA.
Purpose:
A comprehensive metabolic characterization of a patient with dysplastic gangliocytoma of the cerebellum or Lhermitte-Duclos Disease (LDD) is presented.
Procedures:
Assessment using 2-deoxy-2-[18F]fluoro-D-glucose (FDG), carbon-11-labeled methionine (11C-MET), carbon-11-labeled choline (11C-Choline) positron emission tomography (PET), and 1H-proton magnetic resonance spectroscopy (MRS) was carried out in a 30-year-old Caucasian woman.
Results:
FDG-PET revealed hypermetabolism of the tumor. 11C-MET-PET revealed moderate uptake and 11C-Choline showed no uptake. 1H-MRS demonstrated an elevated level of lactate and decreased levels of choline (Cho) and myoinositol.
Conclusion:
Functional imaging in LDD reflects the dual pathological features of neoplasm and hamartoma.
