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Latent TGF-beta binding proteins

V Todorovic1, V Jurukovski, Y Chen

  • 1Department of Cell Biology, New York University, School of Medicine, 550 First Avenue, New York, NY 10016, USA.

The International Journal of Biochemistry & Cell Biology
|September 24, 2004
PubMed

Latent TGF-beta binding proteins are multidomain proteins with a common, highly repetitive structural organization and partially overlapping expression patterns. Latent TGF-beta binding protein-1, -3 and -4 bind latent TGF-beta. TGF-betas are normally secreted as latent complexes, consisting of the mature TGF-beta dimer non-covalently bound to its processed propeptide dimer plus a latent TGF-beta binding protein. The latent TGF-beta binding protein is covalently bound to the propeptide. These binding proteins may perform at least two functions: structural, as components of the matrix, and regulatory, as modulators of TGF-beta availability.

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