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Experimental facial augmentation with hydroxyapatite cement.

Mimi S Kokoska¹, Craig D Friedman, Richard D Castellano

¹Central Arkansas Veterans Healthcare System and the University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Archives of Facial Plastic Surgery

|September 24, 2004

Summary

Preformed hydroxyapatite (HA) implants and HA cement show promise for craniofacial augmentation in rabbits. These materials, used alone or together, were well-tolerated and integrated without adverse reactions.

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Area of Science:

Biomaterials Science
Craniofacial Surgery
Regenerative Medicine

Background:

Hydroxyapatite (HA) is a bioceramic material widely used in bone reconstruction.
Onlay augmentation is a surgical technique to enhance facial contours.

Purpose of the Study:

To evaluate the efficacy and biocompatibility of preformed HA disks and HA cement for onlay augmentation in a rabbit model.

Main Methods:

Prospective study in 16 rabbits.
Implantation of HA disks and HA cement on nasal dorsum and supraorbital bone.
Gross and histologic examination at 3-24 months.

Main Results:

No infections, adverse reactions, or extrusion observed.
HA disks maintained dimensions; HA cement showed a 15% decrease in dimensions.

Related Experiment Videos

Implants were enclosed in vascularized fibrous capsules; HA cement demonstrated osteoconversion and osteointegration.

Conclusions:

Preformed HA implants and HA cement are safe and effective for augmenting non-stress-bearing craniofacial areas.
Combination of HA disks and HA cement promotes osteoconversion in the cement layer.
Further research may explore long-term stability and clinical applications.