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The diagnostic accuracy of computed tomography in pediatric chronic rhinosinusitis
Neil Bhattacharyya1, Dwight T Jones, Micah Hill
1Division of Otolaryngology, Brigham and Women's Hospital, Boston, Mass 02115, USA. neiloy@massmed.org
Insights
Computed tomography (CT) accurately diagnoses pediatric chronic rhinosinusitis (CRS). This imaging technique shows high sensitivity and specificity, aiding in identifying the condition in children.
Area of Science:
- Radiology
- Pediatric Otolaryngology
- Medical Imaging
Background:
- Pediatric chronic rhinosinusitis (CRS) diagnosis can be challenging.
- Computed tomography (CT) is frequently used to evaluate the paranasal sinuses in children.
Purpose of the Study:
- To assess the diagnostic accuracy of CT scans for pediatric CRS.
- To determine the sensitivity, specificity, and predictive values of CT in diagnosing pediatric CRS.
Main Methods:
- Prospective dual cohort study involving children undergoing sinus CT.
- Two groups: children preparing for surgery (diseased) and controls (nondiseased).
- Lund-MacKay scoring system applied to CT scans; receiver operating characteristic curve analysis used.
Main Results:
- Excellent diagnostic accuracy for CT in pediatric CRS (Area Under Curve = 0.923).
- Sensitivity of 86% and specificity of 85% at a Lund score cutoff of 5.
- High negative predictive value for scores ≤2 and high positive predictive value for scores ≥5.
Conclusions:
- CT scans are highly accurate for diagnosing pediatric CRS.
- The predictive value of CT findings is influenced by the prevalence of CRS in the evaluated population.
Objective:
To determine the accuracy of computed tomography (CT) in the diagnosis of pediatric chronic rhinosinusitis (CRS).
Setting:
Multi-institutional prospective dual cohort study.
Methods:
Two cohorts of children undergoing CT of the paranasal sinuses were prospectively evaluated. The first cohort consisted of children undergoing CT in preparation for endoscopic sinus surgery (diseased group). The second cohort consisted of children undergoing CT for nonsinusitis reasons (nondiseased control group). Sinus CT scans were scored according to the Lund-MacKay system. Diagnostic accuracy was quantified with the receiver operating characteristic curve. Sensitivity, specificity, and predictive value analyses were conducted.
Results:
A total of 66 pediatric patients (mean age, 8 years) were studied in the diseased group and exhibited a mean Lund score of 10.4 (95% confidence interval, 9.2-11.5); 192 control patients (mean age, 9 years) exhibited a mean Lund score of 2.8 (95% confidence interval, 2.4-3.2). The area under the curve for the receiver operating characteristic was 0.923 (P<.001), indicating excellent diagnostic accuracy. Adopting a Lund score cutoff of 5 to represent true disease, the CT scan demonstrated a sensitivity and specificity of 86% and 85%, respectively. Lund scores of 2 or less have an excellent negative predictive value, whereas Lund scores of 5 or greater have an excellent positive predictive value (ie, strongly indicate true disease).
Conclusions:
The sinus CT scan demonstrates excellent diagnostic accuracy for the diagnosis of pediatric CRS, with excellent sensitivity and specificity. However, its predictive value depends substantially on the base rate prevalence of CRS in the population being evaluated.
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