Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

First encounter: how pathogens compromise epithelial transport.

Karl Kunzelmann1, Brendan McMorran

  • 1Institut für Physiologie, Universität Regensburg, D-93053 Regensburg, Germany. uqkkunze@mailbox.uq.edu.au

Physiology (Bethesda, Md.)
|September 24, 2004
PubMed
Summary

Pathogenic organisms disrupt body functions by altering signaling pathways, affecting epithelial barriers and inflammation. They manipulate fluid and electrolyte transport by modulating ion channels and transporters, impacting their own survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The scramblase anoctamin 9 controls the immune response in lymphocytes.

Cellular and molecular life sciences : CMLS·2026
Same author

Case Report of Pediatric HPCA-Associated Dystonia: Analysis of Ca<sup>2+</sup> and K<sup>+</sup> Channel Dynamics and Experience With Pallidal Deep Brain Stimulation.

Pediatric neurology·2025
Same author

Anoctamin 9 determines Ca<sup>2+</sup> signals during activation of T-lymphocytes.

Frontiers in immunology·2025
Same author

Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators.

iScience·2025
Same author

Perinatal dysfunction of innate immunity in cystic fibrosis.

Science translational medicine·2025
Same author

Dystonia caused by ANO3 variants is due to attenuated Ca<sup>2+</sup> influx by ORAI1.

BMC medicine·2025

Area of Science:

  • Microbiology
  • Physiology
  • Cell Biology

Background:

  • Pathogenic organisms initiate complex signaling cascades within host cells.
  • These pathways significantly alter host physiological functions, including barrier integrity and immune responses.

Purpose of the Study:

  • To investigate how pathogens influence host cell signaling pathways.
  • To understand the impact of these pathways on epithelial barrier function and fluid/electrolyte transport.

Main Methods:

  • Analysis of signaling pathways activated by pathogens.
  • Examination of changes in epithelial tight junction structure and function.
  • Assessment of ion channel and transporter activity modulation.

Main Results:

Related Experiment Videos

  • Pathogens induce significant alterations in host signaling pathways.
  • Epithelial tight junction barrier structure and function are compromised.
  • Pathogen interactions lead to altered fluid and electrolyte transport via ion channel modulation.

Conclusions:

  • Pathogenic organisms extensively reprogram host cell signaling.
  • Modulation of ion channels and transporters is a key mechanism pathogens use to alter physiological functions.
  • These transport changes can be advantageous or disadvantageous to pathogen survival.