Related Experiment Video
Updated: Aug 22, 2026

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
Published on: October 20, 2022
A hypothesis about the role of adult neurogenesis in hippocampal function
Alejandro F Schinder1, Fred H Gage
1Laboratory of Neuronal Plasticity, Leloir Institute Foundation, 1405 Buenos Aires, Argentina. aschinder@leloir.org.ar
Abstract:
The functional relevance of adult hippocampal neurogenesis has long been a matter of intense experimentation and debate, but the precise role of new neurons has not been sufficiently elaborated. Here we propose a hypothesis in which specific features of newly generated neurons contribute to hippocampal plasticity and function and discuss the most recent and relevant findings in the context of the proposed hypothesis.
Related Concept Videos
Role of Hippocampus in Memory
Neurogenesis and Regeneration of Nervous Tissue
Neuroplasticity

