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Epidemiology of Shigella-associated diarrhea in rural Egyptian children

Remon R Abu-Elyazeed1, Thomas F Wierzba, Robert W Frenck

  • 1U.S. Naval Medical Research Unit No. 3, Cairo, Egypt.

The American Journal of Tropical Medicine and Hygiene
|September 24, 2004
PubMed

Insights

Shigella diarrhea affects young Egyptian children, with incidence at 0.2 episodes/child-year. Breastfeeding offers protection, while younger age and warmer months increase risk, highlighting the need for control measures.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Epidemiology

Background:

  • Shigella diarrhea is a significant pediatric health concern in developing regions.
  • Understanding the epidemiology of Shigella infections is crucial for implementing effective control strategies.

Purpose of the Study:

  • To investigate the incidence and risk factors of Shigella-associated diarrhea in young children in Egypt's Nile Delta.
  • To identify common symptoms and outcomes of Shigella infections in this population.

Main Methods:

  • Prospective cohort study conducted from February 1995 to February 1998.
  • Bi-weekly home visits to children under three years of age in the Nile Delta.
  • Stool sample collection and analysis for Shigella identification.

Main Results:

  • The incidence of Shigella-associated diarrhea was 0.2 episodes per child-year.
  • Shigella flexneri was the predominant serogroup (55%).
  • Younger age and warm months were identified as risk factors; breastfeeding demonstrated a protective effect.

Conclusions:

  • Shigella-associated diarrhea remains prevalent in young Egyptian children.
  • Findings underscore the necessity for enhanced control measures, including the development of a Shigella vaccine.

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