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Updated: Aug 22, 2026

Listeria monocytogenes Infection of the Brain
Published on: October 2, 2018
[Rhombencephalitis caused by Listeria: clinical-radiological correlation]
N Aymerich1, F Lacruz, J Gállego
1Servicio de Neurología, Hospital de Navarra, Pamplona.
Abstract:
Rhombencephalitis due to Listeria is a serious and infrequent infection of the brainstem. It principally affects subjects who were previously healthy. It shows itself clinically in two phases: the first with unspecific symptoms, which could last one week, and the second with the appearance of focal neurologic signs at the level of the brainstem. We present the case of a patient with rhombencephalitis due to Listeria that began initially with headache, nauseas and fever and after ten days the patient showed an asymmetrical affection of cranial nerves, cerebellar signs and sensory deficits in the left hemibody. Subsequently this became complicated with acute respiratory insufficiency, requiring admission to the Intensive Care Unit, and with episodes of urinary retention that required exploration. The early magnetic resonance image showed hypertense patch lesions that were objectified in T2 sequences at the level of the bulb and the pons. Facing a clinical-radiological suspicion of rombencephalitis due to Listeria, treatment was begun with ampicillin and tombramycin. After some days a positive haemoculture for Listeria monocytogenes serotype 4B resistant to ampicilin was detected, therefore it was replaced with vancomycin. The patient survived and on discharge he had oculomotor disorder and micturition problems as sequels. We would like to emphasise the importance of early recognition of the clinical signs of the disease and the early permormance of magnetic resonance, with diagnostic support, to be able to start a suitable antibiotic treatment as quickly as possible.
Insights
Rhombencephalitis, a rare brainstem infection, presents in two phases. Early recognition of symptoms and prompt MRI are crucial for effective antibiotic treatment and improved patient outcomes.
Area of Science:
- Neurology
- Infectious Diseases
Background:
- Rhombencephalitis is an infrequent yet serious brainstem infection.
- It primarily affects previously healthy individuals.
Observation:
- The case details a patient initially presenting with nonspecific symptoms like headache, nausea, and fever.
- This progressed to focal neurological deficits, including cranial nerve asymmetry, cerebellar signs, and sensory deficits.
- Complications included acute respiratory insufficiency and urinary retention.
Findings:
- Early magnetic resonance imaging (MRI) revealed characteristic hyperintense lesions in the brainstem (bulb and pons) on T2 sequences.
- Initial treatment with ampicillin and tobramycin was modified to vancomycin due to Listeria monocytogenes (serotype 4B) resistance to ampicillin.
- The patient survived but experienced residual oculomotor and micturition issues.
Implications:
- Emphasizes the critical role of early clinical recognition of rhombencephalitis signs.
- Highlights the importance of prompt MRI for diagnosis and guiding appropriate antibiotic therapy.
- Underscores the need for timely intervention to improve prognosis and minimize sequelae.
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