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[Postherpetic neuralgia].

Işin Unal Cevik1

  • 1Harvard Medical School, Massachusetts General Hospital, Pain Center, Boston, MA 02114, USA. icevik@partners.org

Agri : Agri (Algoloji) Dernegi'Nin Yayin Organidir = the Journal of the Turkish Society of Algology
|September 24, 2004
PubMed
Summary

Varicella-zoster virus reactivation causes shingles (herpes zoster), a painful skin infection. Early treatment can prevent complications like postherpetic neuralgia (PHN), a chronic pain condition.

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Area of Science:

  • Virology
  • Dermatology
  • Neurology

Context:

  • Varicella-zoster virus (VZV) establishes latent infections in sensory ganglia post-chickenpox.
  • Reactivation of latent VZV leads to herpes zoster (shingles).
  • Shingles presents as a unilateral, dermatomal, vesicular rash, often painful.

Purpose:

  • To describe the pathogenesis, clinical presentation, and complications of herpes zoster.
  • To highlight the risks of postherpetic neuralgia (PHN) and CNS invasion in vulnerable populations.
  • To emphasize the importance of early intervention for shingles management.

Summary:

  • Herpes zoster, caused by VZV reactivation, is a painful, localized skin infection.
  • Elderly and immunocompromised individuals are at higher risk for complications like PHN and CNS invasion.
  • Antiviral, analgesic, and antidepressant therapies are crucial for early intervention and complication risk reduction.

Impact:

  • Early treatment of shingles can mitigate the risk of severe complications, including chronic postherpetic neuralgia.
  • Effective management of PHN, a challenging neuropathic pain syndrome, is critical for improving patient quality of life.
  • Understanding VZV reactivation and its sequelae is essential for clinical practice and patient care.

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