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[Profile of antimicrobial resistance of agents causing urinary tract infections in children]

Leila Ghedira Besbes1, Ahlem Messaoudi, Chebil Ben Meriem

  • 1Service de Pediatrie, Hopital Fattouma Bourguiba, Monastir, Tunisie.

La Tunisie Medicale
|September 24, 2004
PubMed

Insights

Pediatric urinary tract infections show high resistance to common antibiotics like ampicillin. Escherichia coli is the most frequent cause, with third-generation cephalosporins and aminoglycosides remaining effective treatments.

Area of Science:

  • Pediatric infectious diseases
  • Microbiology
  • Antibiotic resistance

Background:

  • Urinary tract infections (UTIs) in children are a common concern.
  • Emergence of antibiotic-resistant bacterial strains complicates UTI management.
  • Understanding local antimicrobial susceptibility patterns is crucial for effective treatment.

Purpose of the Study:

  • To determine the frequency of different bacterial pathogens causing UTIs in hospitalized children.
  • To assess the antibiotic susceptibility profiles of these causative agents.

Main Methods:

  • Retrospective study of 200 pediatric UTI cases hospitalized between January 1995 and December 2000.
  • Data collected on patient demographics, causative organisms, and antibiotic resistance patterns.
  • Analysis of bacterial isolates and their susceptibility testing results.

Main Results:

  • Escherichia coli was the predominant pathogen (75.5%), followed by Proteus mirabilis (10%) and Klebsiella pneumoniae (6%).
  • High resistance rates were observed for ampicillin, amoxicillin, and cefalotin (96%).
  • Third-generation cephalosporins and aminoglycosides showed significant activity against most UTI pathogens, except Pseudomonas.

Conclusions:

  • Escherichia coli is the primary cause of pediatric UTIs in this region.
  • Significant antibiotic resistance necessitates careful selection of antimicrobial therapy.
  • Third-generation cephalosporins and aminoglycosides are recommended for empirical treatment of UTIs in children, pending susceptibility results.
Abstract

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