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Related Experiment Videos

Nanocapsules: coating for living cells.

Silke Krol1, Alberto Diaspro, Raffaella Magrassi

  • 1National Institute for the Physics of Matter (INFM), Department of Physics, University of Genoa, Genoa 33-16146, Italy. krol@fisica.unige.it

IEEE Transactions on Nanobioscience
|September 24, 2004
PubMed
Summary

Nanotechnology, specifically polyelectrolyte (PE) capsules, offers promising applications in medicine. These nano-organized shells can coat cells and tissues, preventing immune responses and enabling targeted material delivery for advanced therapies.

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Area of Science:

  • Nanotechnology
  • Biomaterials Science
  • Materials Chemistry

Background:

  • Self-assembly systems, such as polyelectrolyte (PE) capsules created using the layer-by-layer technique, are crucial for developing nano-organized systems.
  • These nano-organized shells have potential applications in coating living cells or artificial tissues to prevent immune responses and for targeted material delivery to specific organs.

Purpose of the Study:

  • To present preliminary results and provide an overview of the potential applications of nano-organized capsules.
  • To investigate the behavior of PE capsules in biological systems, including their interaction with cell division and their cytotoxicity.

Main Methods:

  • Utilizing confocal laser scanning microscopy to study a mutant yeast strain (Saccharomyces cerevisiae) expressing GFP-tubulin.

Related Experiment Videos

  • Employing fluorescence microscopy to assess the cytotoxicity of PE capsules on germinating conidia of the fungus Neurospora crassa.

    • Main Results:

    • Confocal microscopy revealed an increased surface charge in the bud region of yeast cells prior to encapsulation during cell division.
    • Fluorescence microscopy indicated variations in surface charge between the growing regions and poles of coated fungal conidia, suggesting localized charge differences.

    Conclusions:

    • Nano-organized capsules exhibit properties that make them valuable tools in scientific research.
    • These capsules show promise for future applications in the field of medicine, particularly in areas requiring targeted delivery and biocompatible coatings.