A biomolecular computing method based on Rho family GTPases
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Updated: Aug 22, 2026

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
Published on: November 11, 2018
Jian-Qin Liu1, Katsunori Shimohara
1ATR Human Information Science Laboratories, 2-2-2, Hikaridai, Keihanna Science City, Kyoto 619-0288, Japan. jqliu@atr.co.jp
Abstract:
In this paper, we propose a new biomolecular computing method based on Rho family GTPases, and discuss the schemes of representation and operations of molecular computing by Rho family GTPases applied to solve large-scale 3-SAT problems. We also present the optimal condition for the regulation schemes dependent on the temperature, kinase activity, and types of cells. This work is important for potential implementation of biomolecular computers using Rho family GTPases in which an optimized controlling scheme can make the best use of the interactions of signaling pathways in a computing system made by the large-scale abundance of kinases and phosphatases in cells.
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