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Updated: Aug 22, 2026

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
Published on: April 3, 2015
Dynamics of the cell and its extracellular matrix--a simple mathematical approach
1IRIS, Swinburne University of Technology, PO Box 218, Hawthorn, Melbourne, Vic. 3122, Australia.
Abstract:
The extracellular matrix (ECM) is produced by the cells and secreted into the surrounding medium, and consists of a complex mixture of structural and functional proteins. It has been recently observed that the ECM can influence the behavior of cell growth in vitro quite remarkably. A simple mathematical model has been constructed based on negative feedback control mechanisms to represent the dynamics of ECM deposition and cellular differentiation. The model analysis shows a strong relationship between the numerical solution and the experimental observations in cell-polymer constructs for the design of engineered cartilage. The current paper may be a useful guide for those who want to explore the studies on cell-matrix interactions.
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