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Association of parental eczema, hayfever, and asthma with atopic dermatitis in infancy: birth cohort study

N Wadonda-Kabondo1, J A C Sterne, J Golding

  • 1Department of Child Health, University of Bristol, Bristol, UK.

Archives of Disease in Childhood
|September 24, 2004
PubMed

Insights

Parental eczema significantly increases the risk of childhood atopic dermatitis, regardless of the parent

Area of Science:

  • Pediatrics
  • Genetics
  • Dermatology

Background:

  • Atopic dermatitis (eczema) is a common inflammatory skin condition in children.
  • Parental history of atopic diseases is a known risk factor for childhood atopic dermatitis.
  • Previous studies have suggested a stronger maternal influence on atopic dermatitis inheritance.

Purpose of the Study:

  • To investigate the association between parental history of atopic disease and childhood atopic dermatitis.
  • To compare the relative strength of association between maternal and paternal atopic disease and childhood atopic dermatitis.

Main Methods:

  • Utilized data from the Avon Longitudinal Study of Parents and Children (ALSPAC).
  • Collected parental history of eczema, asthma, and hayfever before birth.
  • Tracked childhood atopic dermatitis symptoms at multiple time points (6, 18, 30, 42 months).

Main Results:

  • Strong associations were found between parental eczema and childhood atopic dermatitis.
  • Odds ratios for maternal eczema only: 1.69; paternal eczema only: 1.74; both parents: 2.72.
  • Associations with parental asthma or hayfever were weaker and attenuated by parental eczema.
  • No significant difference in association strength between maternal and paternal atopy.

Conclusions:

  • Parental atopic disease type, specifically eczema, is associated with childhood atopic dermatitis risk.
  • The risk is not influenced by parental sex, challenging the notion of a 'parent-of-origin' effect.
  • Parental eczema appears to be a more significant predictor of childhood eczema than parental asthma or hayfever.
Abstract

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