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[Indinavir and renal lithiasis].

Ma L Traba Villameytide1, M Fernández-Guerrero

  • 1Laboratorio de Bioquímica, Sección de Fisiopatología Osea, Medicina Interna, Fundación Jiménez Díaz, Madrid.

Actas Urologicas Espanolas
|September 24, 2004
PubMed
Summary

Indinavir treatment for HIV/AIDS can cause crystalluria and kidney stones in some patients. This study analyzed urinary crystals and a renal stone to understand drug-related renal complications.

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Area of Science:

  • Pharmacology
  • Nephrology
  • Virology

Context:

  • Indinavir is a protease inhibitor used in HIV/AIDS treatment.
  • Antiretroviral therapy aims to reduce viral load and increase CD4 counts.
  • Drug-induced nephrotoxicity is a concern in managing chronic infections.

Purpose:

  • To investigate the incidence of crystalluria and renal calculi in patients treated with indinavir.
  • To analyze the characteristics of urinary crystals and kidney stones formed during indinavir therapy.

Summary:

  • This study examined nine patients undergoing indinavir treatment for HIV/AIDS.
  • Two patients exhibited significant crystalluria, and one passed a renal stone.
  • Urinary crystals were analyzed using polarized-light microscopy, and the renal stone by infrared spectroscopy.

Impact:

  • Findings highlight the potential for indinavir to cause renal complications.
  • Understanding crystalluria and stone formation aids in patient monitoring and management.
  • This research contributes to the safe use of antiretroviral drugs in clinical practice.

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