Related Experiment Video
Updated: Aug 22, 2026

06:51
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
A calcium-calmodulin antagonist blocks experimental Vibrio vulnificus cytolysin-induced lethality in an experimental
Young-Rae Lee1, Kwang-Hyun Park, Zhao-Zhen Lin
1Department of Biochemistry, Chonbuk National University Medical School, Chonju, Republic of Korea.
Infection and Immunity
|September 24, 2004
Abstract:
We demonstrated that trifluoperazine, a calcium-calmodulin antagonist, blocked the hyperpermeability induced by Vibrio vulnificus cytolysin in in vitro-modeled endothelium and prevented the deaths of mice. Furthermore, compared to tetracycline alone, tetracycline combined with trifluoperazine enhanced the survival rate of V. vulnificus-infected mice, indicating the role of the cytolysin as an important factor in pathogenesis.

