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Updated: Aug 7, 2026

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
Published on: November 11, 2017
Stochastic properties of synaptic transmission affect the shape of spike time-dependent plasticity curves
Harel Z Shouval1, Georgios Kalantzis
1Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX 77030, USA. harel.shouval@uth.tmc.edu
Abstract:
Theoretical studies have shown that calcium influx through N-methyl-D-aspartate (NMDA) receptors is a sufficient signal to account for various induction protocols of bidirectional synaptic plasticity, including spike time-dependent plasticity (STDP). The STDP curves obtained by these different models exhibits a form of spike time-dependent long-term depression that occurs when a presynaptic spike precedes the postsynaptic spike (pre-post LTD). We have previously proposed that this novel form of LTD can serve as an experimental test for the validity of these models. These calcium based theoretical models assumed deterministic calcium dynamics that reflect average properties of synaptic calcium currents. In this paper, we show that taking into account the stochastic properties of synaptic transmission significantly alters the form of STDP curves and may significantly reduce the magnitude of pre-post LTD.
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