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Prohaptoglobin is proteolytically cleaved in the endoplasmic reticulum by the complement C1r-like protein

Krzysztof B Wicher1, Erik Fries

  • 1Department of Medical Biochemistry and Microbiology, Uppsala University, P.O. Box 582, S-751 23 Uppsala, Sweden. krzysztof.wicher@imbim.uu.se

Proceedings of the National Academy of Sciences of the United States of America
|September 24, 2004
PubMed
Summary

Complement C1r-like protein (C1r-LP) cleaves haptoglobin (Hp) proform in the endoplasmic reticulum. This newly identified proteolytic activity of C1r-LP is crucial for Hp maturation before entering the Golgi apparatus.

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