Related Experiment Video
Updated: Aug 22, 2026
Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme
Eun Young Bae1, Hyuncheol Oh, Won Keun Oh
1Korea Research Institute of Bioscience and Biotechnology (KRIBB), 52 Eoeun-dong, Yusong, Taejeon 305-333, South Korea.
Abstract:
Bioassay-guided fractionation of the EtOAc-soluble extract of Dendrobium moniliforme afforded a new phenanthraquinone-type metabolite, 7-hydroxy-5,6-dimethoxy-1,4-phenanthrenequinone ( 1), along with the previously reported 5-hydroxy-3,7-dimethoxy-1,4-phenanthrenequinone ( 2). The structures of the compounds were identified mainly on the basis of MS and NMR data. Compound 1 inhibited VHR dual-specificity protein tyrosine phosphatase (DS-PTPase) activity in a dose-dependent manner, displaying an IC (50) value of 3.0 +/- 0.2 microM.
