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AT4 receptor binding in the developing rabbit.

Gilbert A Burns1, Thiessen Ann-Marie, Hanesworth Jodie

  • 1Department of Veterinary Comparative Anatomy, Pharmacology, and Physiology, College of Veterinary Medicine, Room 205 Wegner Hall, Washington State University, Pullman, WA 99164, USA. gil_burns@wsu.edu

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
|September 24, 2004
PubMed
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Researchers studied how a specific molecule, divalinal-AngIV (Dival), binds to AT(4) receptors in developing rabbit fetuses. They found Dival binding sites are present in various fetal tissues, with nerves, kidneys, and heart showing high concentrations.

Area of Science:

  • Pharmacology
  • Developmental Biology
  • Neuroscience

Background:

  • The AT(4) receptor system plays a role in physiological processes.
  • Understanding fetal receptor expression is crucial for developmental studies.

Purpose of the Study:

  • To investigate the binding characteristics of the AT(4)-specific analog, divalinal-AngIV (Dival), in rabbit fetuses.
  • To determine the distribution and developmental changes of AT(4) binding sites in fetal tissues.

Main Methods:

  • Saturation isotherm and competition binding assays were performed on selected fetal tissues.
  • Autoradiography was used to visualize and quantify Dival binding site distribution.

Main Results:

  • Fetal Dival binding sites were confirmed to be saturable and specific for AT(4) ligands.

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  • Autoradiography revealed widespread Dival binding across all examined fetal specimens.
  • Peripheral nerves, kidneys, and heart demonstrated particularly high levels of binding.
  • Binding in tissues like developing bones varied with gestational age.
  • Substantial binding was observed in developing tissues such as multilocular fat, sinus hairs, and tooth enamel organs.

    • Conclusions:

    • AT(4) receptors are expressed in a variety of rabbit fetal tissues.
    • The distribution of AT(4) binding sites changes during fetal development.
    • These findings provide insights into the role of the AT(4) system during mammalian fetal development.