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Related Experiment Videos

[CD5- CD11c+ CD23- small lymphocytic lymphoma evolving from aplastic anemia].

Motoo Kikuchi1, Toshiaki Inagaki, Ryuzo Ueda

  • 1Department of Medicine, Nagoya-Shi Kouseiin Medical Welfare Center.

Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
|September 25, 2004
PubMed
Summary
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Aplastic anemia evolved into a rare small lymphocytic lymphoma in an elderly patient. Treatment with rituximab showed some improvement, highlighting a unique case of lymphoma with specific cell markers.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • A 91-year-old woman initially diagnosed with aplastic anemia (AA) in 1997.
  • AA was characterized by pancytopenia and hypocellular bone marrow without myeloblasts or dysplasia.

Observation:

  • The patient presented with persistent fever and leukopenia in 2001.
  • Bone marrow examination revealed small lymphocytic proliferation with a unique immunophenotype (CD5- CD10- CD11c+ CD19+ CD20+ CD23-).
  • Genetic analysis showed immunoglobulin heavy chain rearrangement and abnormal chromosomes.

Findings:

  • A diagnosis of small lymphocytic lymphoma (SLL) evolving from AA was made.
  • Treatment with rituximab resulted in decreased lactate dehydrogenase and soluble interleukin-2 receptor levels.

Related Experiment Videos

  • Partial improvement in platelet and erythrocyte counts and overall systemic condition was observed.

    • Implications:

    • This case highlights a rare SLL subtype with a distinct CD marker profile.
    • The evolution of AA to SLL presents a unique clinical scenario.
    • Rituximab demonstrated potential efficacy in managing this rare lymphoma subtype, despite incomplete remission.