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[Organ procurement after poisoning].

Philippe Hantson1

  • 1Unité de neurotraumatologie et toxicologie, Département des soins intensifs Cliniques St-Luc, Université catholique de Louvain, Bruxelles, Belgique. hantson@rean.ucl.ac.be

Presse Medicale (Paris, France : 1983)
|September 25, 2004
PubMed
Summary

Poisoned individuals can be viable organ donors, despite historical contraindications. Careful assessment of toxins and target organs can lead to encouraging outcomes for organ transplantation recipients.

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Area of Science:

  • Transplantation medicine
  • Toxicology
  • Organ donation

Context:

  • Growing organ transplant waiting lists necessitate consideration of "marginal" donors.
  • Poisoned patients, previously excluded, represent a potential donor pool.
  • In France, over 10,000 patients awaited organ transplants in 2002.

Purpose:

  • To evaluate the potential of organ donation from patients deceased due to poisoning.
  • To review criteria for selecting poisoned donors and assess outcomes.
  • To address the controversy surrounding organ procurement from poisoned individuals.

Summary:

  • Poisoned donors constitute ~1% of organ donors in Europe/North America, often under-referred due to contraindication concerns.
  • Commonly implicated toxins include drugs, illicit substances, and environmental agents.
  • Successful organ procurement requires confirming brain death and understanding the poisoning's toxicokinetics and target organs.

Impact:

  • Encouraging recipient and graft survival rates are reported when organ procurement from poisoned donors is successful.
  • This approach can help alleviate organ shortages.
  • Further research and standardized protocols can optimize the use of this donor pool.

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