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The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation
Published on: July 17, 2018
New scalarane-based sesterterpenes from the sponge Phyllospongia madagascarensis
Ljudmila P Ponomarenko1, Anatoly I Kalinovsky, Valentin A Stonik
1Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok 690022, Russia.
Abstract:
Two new natural scalaranes, 16beta-acetoxy-20,24-dimethyl-12,24-dioxo-25-norscalarane and 12beta-hydroxy-20,24-dimethyl-13,18-oxa-25-norscalarane, were isolated from the Madagascaran sponge Phyllospongiamadagascarensis, together with three previously decribed tetracyclic sesterterpenoids, phyllofolactones F, G, and B, and a new artifactual ethyl ether of scalaradisin B. Structure determinations were based on NMR and other spectral data. Compounds 1 and 2 represent new examples of 20,24-dimethyl-25-norscalarane sesterterpenes, and compound 2 has a seven-membered oxacycle that makes its skeletal system unique.
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