A cytotoxic cyclic heptapeptide from the seeds of Annona cherimola
Related Experiment Video
Updated: Aug 22, 2026

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation
Published on: January 26, 2016
Alassane Wélé1, Yanjun Zhang, Idrissa Ndoye
1Laboratoire de Chimie Organique et Thérapeutique, Faculté de Médecine et de Pharmacie, Université Cheikh Anta Diop Dakar-Fann, Sénégal. alassanewele@yahoo.fr
Abstract:
From a methanol extract of the seeds of Annona cherimola, a new cyclic heptapeptide, cherimolacyclopeptide C, has been isolated. The structure was elucidated on the basis of the MS/MS fragmentation using a Q-TOF mass spectrometer equipped with an ESI source, extensive 2D NMR experiments, and chemical degradation. Cherimolacyclopeptide C exhibited significant in vitro cytotoxic activity against KB cells, with an IC(50) value of 0.072 microM.
Related Concept Videos
Anaphase Promoting Complex
Caspases

