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Related Experiment Videos

Common variable immunodeficiency: diagnosis by absent ABO reverse type.

C J Julius1, M Wade, A Waheed

  • 1Department of Pathology, The Ohio State University Medical Center, 310 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA.

Immunohematology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Common variable immunodeficiency (CVID) can cause ABO discrepancies in adults due to absent reverse typing. This case highlights CVID as a cause of unexpected blood type inconsistencies in younger patients.

Area of Science:

  • Immunology
  • Transfusion Medicine
  • Hematology

Background:

  • ABO discrepancies between red blood cell and serum testing are documented.
  • Weak or absent reverse typing, often seen in the very young or elderly, can cause ABO discrepancies.
  • The case involves a 25-year-old woman presenting for dental surgery.

Purpose of the Study:

  • To report a case of ABO discrepancy in an adult patient.
  • To identify the underlying cause of the ABO discrepancy.
  • To highlight a rare cause of ABO discrepancy in adults.

Main Methods:

  • Serologic workup for ABO discrepancy.
  • Immunoglobulin level testing.
  • Patient medical history review.

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Main Results:

  • The patient, group A, D+, showed a complete absence of anti-B isohemagglutinin.
  • Laboratory tests revealed decreased levels of all immunoglobulin classes.
  • The patient had a history of recurrent infections.

Conclusions:

  • The patient was diagnosed with common variable immunodeficiency (CVID).
  • CVID can manifest as an absent ABO reverse type in adult patients.
  • This case underscores the importance of considering immunodeficiency in adult ABO discrepancies.