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Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
Published on: November 9, 2018
Tritium in [18O]water containing [18F]fluoride for [18F]FDG synthesis
Shigeki Ito1, Takuya Saze, Hitoshi Sakane
1Radioisotope Research Center and Graduate School of Environmental Studies, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan.
Abstract:
The presence of tritium in enriched [18O]water irradiated with 9.6 MeV protons used to produce [18F]fluoride by the 18O(p, n)18F reaction was inferred from the cross sections and threshold energies of the 18O(p, t)16O reaction, and the existence of tritium was confirmed experimentally. Tritium was also detected in both [18O]water recovered for recycling and waste acetonitrile solutions. The purified [18F]FDG was not contaminated with 3H. The amount of 3H discharged into the air was far less than the International Basic Safety Standard Level.
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