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Related Experiment Videos

A potential aphrodisiac for female macaques.

Antti Pertovaara1, Ilkka Linnankoski, Denis Artchakov

  • 1Neuroscience Unit, Helsinki Brain Research Center, Institute of Biomedicine/Physiology, University of Helsinki, Helsinki, Finland. antti.pertovaara@utu.fi

Pharmacology, Biochemistry, and Behavior
|September 25, 2004
PubMed
Summary

A selective alpha2-adrenoceptor antagonist increased male stumptail macaque sexual activity when given to females. This suggests the antagonist may enhance female sexual arousal, indirectly boosting male sexual behavior.

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Area of Science:

  • Primate reproductive behavior
  • Neuropharmacology of sexual function

Background:

  • Previous research indicates alpha2-adrenoceptor antagonists and dopamine receptor agonists may enhance male primate sexual activity.
  • The effects of these compounds on female primate sexual behavior remain largely unexplored.

Purpose of the Study:

  • To investigate the influence of a selective alpha2-adrenoceptor antagonist (atipamezole) and a dopamine receptor agonist (apomorphine) on the sexual behavior of female Macaca arctoides (stumptail macaques).

Main Methods:

  • Female stumptail macaques were administered atipamezole, apomorphine, or a combination thereof.
  • Following drug administration, female-male sexual interactions were observed for 30 minutes.

Main Results:

  • Atipamezole administration dose-dependently increased male mounting behavior and the total number of copulations.

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  • Apomorphine, alone or in combination with atipamezole, did not significantly alter sexual behavior.

    • Conclusions:

    • Selective alpha2-adrenoceptor antagonists administered to female stumptail macaques can increase male sexual activity.
    • This effect may be mediated by enhanced female sexual arousal, leading to changes in psychosocial interactions that stimulate increased male sexual behavior.