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Antistaphylococcal activity of CB-181963 (CAB-175), an experimental parenteral cephalosporin
Dianne B Hoellman1, Glenn A Pankuch, Peter C Appelbaum
1Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Abstract:
Among 265 methicillin-susceptible and -resistant staphylococci, CB-181963 (CAB-175) had a 50% minimum inhibitory concentration of 2 microg/ml and a 90% minimum inhibitory concentration of 4 microg/ml. All strains except two vancomycin-resistant S. aureus and 5 vancomycin-intermediate S. aureus strains were also susceptible to vancomycin and teicoplanin, and all were susceptible to linezolid, ranbezolid, tigecycline, and quinupristin-dalfopristin. Most methicillin-resistant strains were levofloxacin resistant. CB-181963 was bactericidal against all six methicillin-resistant strains at four times the MIC after 24 h.
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