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Bounds and normalization of the composite linkage disequilibrium coefficient
1Genetic Data Sciences, GlaxoSmithKline Inc., Research Triangle Park, North Carolina 27709, USA. dmitri.v.zaykin@gsk.com
Genetic Epidemiology
|September 25, 2004
Summary
The composite linkage disequilibrium (LD) measure
Area of Science:
- Population Genetics
- Statistical Genetics
Background:
- Composite linkage disequilibrium (LD) is frequently used for two-locus genotypic data analysis.
- It is particularly useful when distinguishing between coupling and repulsion double heterozygotes is not possible.
- Previous research suggested its routine use due to favorable statistical properties, irrespective of Hardy-Weinberg equilibrium.
Purpose of the Study:
- To derive the bounds for the composite linkage disequilibrium measure.
- To establish standardized measures of composite LD based on allele or genotype frequencies.
Main Methods:
- Derivation of bounds for the composite LD measure.
- Expressing these bounds as functions of one-locus genotype or allele frequencies.
Main Results:
- The study successfully derived the bounds for the composite LD measure.
- These bounds are presented as functions of one-locus genotype or allele frequencies.
- The derived bounds allow for standardized composite LD measures.
Conclusions:
- The derived bounds provide a framework for interpreting composite LD.
- Standardized composite LD measures enhance the analysis of genetic associations.
- This work facilitates a more robust understanding of linkage disequilibrium patterns.
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