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A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
Published on: June 13, 2025
Effects of rivastigmine on motor and cognitive impairment in Huntington's disease
Marina de Tommaso1, Nicola Specchio, Vittorio Sciruicchio
1Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy. m.detommaso@neurol.uniba.it
Abstract:
To evaluate the efficacy of rivastigmine on motor and cognitive impairment in Huntington's disease (HD), we carried out a prospective, open-label, randomized, controlled study. Twenty-one HD patients were enrolled: 14 were randomly sorted into medication and 7 to no-treatment groups. Clinical and demographic features were similar between groups. After 8 months, an efficacy evaluation was carried out to compare the two groups. The improvement of cholinergic transmission in HD patients seemed to have a slight effect in ameliorating cognitive performance and slowing motor deterioration.
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