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Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
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Modified Spared Nerve Injury Surgery Model of Neuropathic Pain in Mice
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A comparison of two approaches to sciatic nerve block.

A W Kilpatrick1, D M Coventry, J G Todd

  • 1Division of Anaesthesia, Western Infirmary, Glasgow.

Anaesthesia
|February 1, 1992
PubMed
Summary

The posterior approach for sciatic nerve block demonstrated higher success rates (95%) compared to the popliteal fossa approach (45%) for foot surgery. Both methods showed similar onset and duration, but the posterior approach is recommended.

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Area of Science:

  • Anesthesiology
  • Surgical Procedures

Background:

  • Sciatic nerve blocks are crucial for lower limb surgery.
  • Choosing the optimal approach is essential for efficacy and patient comfort.

Purpose of the Study:

  • To compare the efficacy and outcomes of posterior versus popliteal fossa approaches for sciatic nerve blocks.

Main Methods:

  • Randomized comparison of 40 patients undergoing foot surgery.
  • Sciatic nerve blocks performed using posterior (n=20) or popliteal fossa (n=20) approaches.
  • Utilized peripheral nerve stimulator and standardized local anesthetic (bupivacaine with adrenaline).

Main Results:

  • The posterior approach achieved significantly higher success rates (19/20) than the popliteal fossa approach (9/20; p<0.01).
  • No significant differences were observed in block onset time or duration between the two groups.
  • Popliteal fossa approach resulted in less procedural discomfort but required more supplementary blocks.

Conclusions:

  • The posterior approach is recommended for sciatic nerve blocks due to its superior success rate.
  • While the popliteal fossa approach offers comfort, its lower efficacy necessitates further interventions.